Reference library
Conserved cell types with divergent features in human versus mouse cortex.
Paper summary
Uses single-nucleus RNA sequencing to classify human cortical cells and compare homologous mouse types. Broad cellular organization is conserved, but proportions, gene expression, layer distribution, and morphology differ substantially.
Relevance to the project
Helps qualify human-versus-animal neuron analogies and distinguish conserved capabilities from detailed implementation. More types remain an optional extension.
Molecular similarity does not imply identical physiological behavior.
Source record
- Reference ID
- doi-10-1038-s41586-019-1506-7
- Archived version
- Europe PMC hosted article; publication/manuscript status is specified in source XML
- Summary provenance
- reference-library/papers/doi-10-1038-s41586-019-1506-7/metadata.json · summary
- Review status
- initial orientation summary; not a critical full-paper review
- Reading scope
- Selected abstract/opening and available closing discussion/conclusion passages in the preserved text extract; broader project notes provide context. No reproduction of experiments, exhaustive methods review, or equation/figure audit.