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Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type

Paper summary

Paired stimulation of cultured hippocampal neurons produces potentiation or depression according to relative spike timing. Initial synaptic strength and postsynaptic cell type also influence the changes.

Relevance to the project

Supports including local histories when evaluating adaptive connection rules. Any biological timing analogy must remain separate from an adopted project update law.

Biological neuronsSynaptic plasticitySynaptic communication

Pair-based timing curves are not a complete account of synaptic learning.

Source record

Reference ID
pdf-https-www-gatsby-ucl-ac-uk-pel-course-wuhan-papers-bi-poo-1998-pdf
Archived version
Direct PDF cited in project notes; publication status needs source-specific inspection; PMC article HTML; manuscript/publication label retained in source
Summary provenance
reference-library/papers/pdf-https-www-gatsby-ucl-ac-uk-pel-course-wuhan-papers-bi-poo-1998-pdf/metadata.json · summary
Review status
initial orientation summary; not a critical full-paper review
Reading scope
Selected abstract/opening and available closing discussion/conclusion passages in the preserved text extract; broader project notes provide context. No reproduction of experiments, exhaustive methods review, or equation/figure audit.