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Pyramidal cell regulation of interneuron survival sculpts cortical networks.

Paper summary

Shows in mice that pyramidal-cell activity during a developmental window influences interneuron survival. Synaptic input predicts survival, with PTEN-related signaling implicated in the regulation of inhibitory-cell numbers.

Relevance to the project

A second source for activity-dependent population regulation. Distinguish developmental survival from adult turnover and from energy-based entity death in the current baseline.

Biological neuronsNeural population developmentSynaptic communication

The result is specific to the studied developmental context.

Source record

Reference ID
pmid-29849154
Archived version
Europe PMC hosted article; publication/manuscript status is specified in source XML
Summary provenance
reference-library/papers/pmid-29849154/metadata.json · summary
Review status
initial orientation summary; not a critical full-paper review
Reading scope
Selected abstract/opening and available closing discussion/conclusion passages in the preserved text extract; broader project notes provide context. No reproduction of experiments, exhaustive methods review, or equation/figure audit.